Ubuchopho bulawula ama-lysophospholipids emizimba yethu, nawo alawula uhlelo olusebenzisa ukudla okunomsoco / izithimbi ezithile ze-lipid synthesis zingasebenza njengezindlela zokwelapha ezintsha zokukhuluphala / ukushicilelwa ku-'Nature Metabolism'.
Iqembu labacwaningi lenze indlela entsha ngokuphelele yokwelapha izinkinga zokudla. Ososayensi babonise ukuthi iqembu lamangqamuzana ezinzwa ku-hypothalamus (okuthiwa i-AgRP, ama-peptide neurons ahlobene ne-agouti) alawula ukukhululwa kwama-lysophospholipids angaphakathi, abuye alawule ukujabula kwamangqamuzana ezinzwa ku-cerebral cortex, okukhuthaza ukudla.
Kule nqubo, isinyathelo esibalulekile sendlela yokubonisa ilawulwa yi-enzyme autotaxin, enesibopho sokukhiqizwa kwe-lysophosphatidic acid (LPA) ebuchosheni njengemoduli yomsebenzi wenethiwekhi.
The nokuphathwa ama-autotaxin inhibitors angakwazi ngaleyo ndlela ukunciphisa ngokuphawulekayo kokubili ukudla ngokweqile ngemva kokuzila ukudla nokukhuluphala kumamodeli ezilwane. I-athikili ethi 'AgRP neurons alawula ukuziphatha kokudla kuma-cortical synapses ngama-lysophospholipids asuselwa ku-peripherally' isivele ku-Nature Metabolism.
Ukuphazamiseka kwemikhuba yokudla futhi ikakhulukazi ukukhuluphala ngokweqile kungenye yezimbangela ezivame kakhulu zezifo ezihlukahlukene emiphakathini yezimboni emhlabeni wonke, ikakhulukazi izifo zenhliziyo nemithambo yegazi ezinokukhubazeka okungapheli noma imiphumela ebulalayo njengokuhlaselwa yinhliziyo, isifo sikashukela, noma unhlangothi.
I-Robert Koch Institute yabika ngo-2021 ukuthi amaphesenti angu-67 amadoda namaphesenti angu-53 abesifazane baseJalimane bakhuluphele ngokweqile. Amaphesenti angu-23 abantu abadala akhuluphele kakhulu (ekhuluphele). Imizamo yokuba nomthelela endleleni odla ngayo ngemithi kuze kube manje ibonakale ingasebenzi.
Ukwelapha okunoveli okushintsha injabulo yamanethiwekhi alawula indlela yokudla kungaba isinyathelo esiwujuqu sokulawula lokhu kukhuluphala okusabalele. Ithimba labacwaningi lithole izinga elikhulayo lokukhuluphala kanye ne-Type II yesifo sikashukela kubantu abanokukhubazeka kwe-synaptic LPA.
Iqembu eliholwa uSolwazi Johannes Vogt (I-Faculty of Medicine, University of Cologne), uSolwazi Robert Nitsch (Faculty of Medicine, University of Münster) kanye noProfessor Thomas Horvath (Yale School of Medicine, New Haven, USA) manje selikhombisile ukuthi ukulawula ukuthakasela kwama-neurons ku-cerebral cortex yi-LPA kudlala indima ebalulekile ekulawuleni ukuziphatha kokudla: I-AgRP neurons ilawula inani le-lysophosphatidylcholine (LPC) egazini.
Ngokuhamba okusebenzayo, i-LPC ifinyelela ebuchosheni, lapho iguqulwa yi-enzyme autotaxin (ATX) ibe yi-LPA, esebenzayo ku-synapse. Izimpawu ze-Synaptic LPA zivuselela amanethiwekhi athile ebuchosheni, ngaleyo ndlela kuholele ekwandeni kokudla.
Kumodeli yegundane, ngemva kwesikhathi sokuzila ukudla ukwanda kwe-LPC egazini kwaholela ekwandeni kwe-LPA evuselelayo ebuchosheni. Lawa magundane abonise ukuziphatha okujwayelekile kokufuna ukudla. Kokubili kungenziwa kube ngokwejwayelekile ngokuphatha ama-autotaxin inhibitors. Amagundane akhuluphele, ngakolunye uhlangothi, ehle isisindo lapho lawa ma-inhibitors elawulwa ngokuqhubekayo.
Johannes Vogt, Uprofesa e-Faculty of Medicine, eNyuvesi yaseCologne:
"Sibone ukwehla okukhulu kokudla ngokweqile nokukhuluphala ngokuguquguquka kwezakhi zofuzo kanye nokuvinjwa kwemithi ye-ATX."
"Okutholakele kwethu okuyisisekelo ekuthokozeni kobuchopho okulawulwa yi-LPA, esisebenze kukho iminyaka, ngakho-ke kudlala indima ebalulekile ekuziphatheni kokudla."
"Sibone ukwehla okukhulu kokudla ngokweqile nokukhuluphala ngokuguquguquka kwezakhi zofuzo kanye nokuvinjwa kwemithi ye-ATX."
"Okutholakele kwethu okuyisisekelo ekuthokozeni kobuchopho okulawulwa yi-LPA, esisebenze kukho iminyaka, ngakho-ke kudlala indima ebalulekile ekuziphatheni kokudla."
Robert Nitsch, Uprofesa e-Faculty of Medicine, University of Münster:
"Imininingwane ikhombisa ukuthi abantu abanendlela yokusayina ye-synaptic LPA ephazamisekile kungenzeka ukuthi bakhuluphele futhi baphathwe isifo sikashukela sohlobo II."
"Lokhu kuwuphawu oluqinile lwempumelelo yokwelapha engaba khona ye-ATX inhibitors, okwamanje esiyithuthukisayo kanye ne-Hans Knöll Institute eJena ukuze isetshenziswe kubantu."
Lokhu okutholakele ekulawuleni okujabulisayo kwamanethiwekhi e-neuronal ekuziphatheni kokudla ngama-lysophospholipids kanye namathuba amasha okwelapha abaphakamisa ukuthi esikhathini esizayo kungaba nomthelela hhayi ekwelapheni ukuphazamiseka kwemikhuba yokudla kuphela, kodwa nasezifo zemizwa nezengqondo.